Nonspecific phosphodiesterase inhibition attenuates liver injury in acute endotoxemia.

Raul R Coimbra, Rafael Dib RD Porcides, Heidi H Melbostad, William W Loomis, Maria M Tobar, David B DB Hoyt and Paul P Wolf Surg Infect (Larchmt) 6(1):73-85 (2005)
PMID 15865553

Endotoxemia is accompanied by pro-inflammatory cytokine production, generation of reactive oxygen species, and end-organ injury. Pentoxifylline (PTX), a methylxanthine derivative and phosphodiesterase inhibitor, is known for its anti-inflammatory properties, including down-regulation of interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha synthesis. Its effects on liver function and hepatic histology following acute endotoxemia have not been investigated fully. We hypothesized that PTX would preserve liver architecture and function after intravenous lipopolysaccharide (LPS) injection.

DOI: 10.1089/sur.2005.6.73
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